Sequence variation in ZFX introns in human populations
نویسندگان
چکیده
منابع مشابه
CpG islands in human ZFX and ZFY and mouse Zfx genes: sequence similarities and methylation differences.
The human ZFX, human ZFY, and mouse Zfx genes have CpG islands near their 5; ends. These islands are typical in that they span about 1.5 kb, contain transcription initiation sites, and encompass some 5' untranslated exons and introns. However, comparitive nucleotide sequencing of these human and mouse islands provided evidence of evolutionary conservation to a degree unprecedented among mammali...
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DNA sequencing can be costly and time consuming for population studies because of the relative rarity of variation along exons. These problems can be substantially reduced by the use of the polymerase chain reaction on introns using primers from the exon region. These problems can be further reduced by the use of denaturing gradient gel electrophoresis to identify those alleles in need of seque...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 1998
ISSN: 0737-4038,1537-1719
DOI: 10.1093/oxfordjournals.molbev.a025910